Selected publications (link to all publications):

Netzer, R.; Listov, D.; Lipsh, R.; Dym, O.; Albeck, S.; Knop, O.; Kleanthous, C.; Fleishman, S. J. Ultrahigh Specificity in a Network of Computationally Designed Protein-Interaction Pairs. Nat. Commun. 2018.
Khersonsky, O.; Lipsh, R.; Avizemer, Z.; Ashani, Y.; Goldsmith, M.; Leader, H.; Dym, O.; Rogotner, S.; Trudeau, D. L.; Prilusky, J.; Amengual-Rigo, P.; Guallar, V.; Tawfik, D. S.; Fleishman, S. J. Automated Design of Efficient and Functionally Diverse Enzyme Repertoires. Mol. Cell 2018.
Lapidoth, G.; Khersonsky, O.; Lipsh, R.; Dym, O.; Albeck, S.; Rogotner, S.; Fleishman, S. J. Highly Active Enzymes by Automated Combinatorial Backbone Assembly and Sequence Design. Nat. Commun. 2018.
Baran, D.; Pszolla, M. G.; Lapidoth, G. D.; Norn, C.; Dym, O.; Unger, T.; Albeck, S.; Tyka, M. D.; Fleishman, S. J. Principles for Computational Design of Binding Antibodies. Proc. Natl. Acad. Sci. U. S. A. 2017.
Campeotto, I.; Goldenzweig, A.; Davey, J.; Barfod, L.; Marshall, J. M.; Silk, S. E.; Wright, K. E.; Draper, S. J.; Higgins, M. K.; Fleishman, S. J. One-Step Design of a Stable Variant of the Malaria Invasion Protein RH5 for Use as a Vaccine Immunogen.Proc. Natl. Acad. Sci. U. S. A. 2017.
Goldenzweig, A.; Goldsmith, M.; Hill, S. E.; Gertman, O.; Laurino, P.; Ashani, Y.; Dym, O.; Unger, T.; Albeck, S.; Prilusky, J.; Lieberman, R. L.; Aharoni, A.; Silman, I.; Sussman, J. L.; Tawfik, D. S.; Fleishman, S. J. Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. Mol. Cell 2016.
Elazar, A.; Weinstein, J. J.; Prilusky, J.; Fleishman, S. J. Interplay between Hydrophobicity and the Positive-inside Rule in Determining Membrane-Protein Topology. Proc. Natl. Acad. Sci. U. S. A. 2016.
Elazar, A.; Weinstein, J.; Biran, I.; Fridman, Y.; Bibi, E.; Fleishman, S. J. Mutational Scanning Reveals the Determinants of Protein Insertion and Association Energetics in the Plasma Membrane. Elife 2016.
Fleishman, S. J.; Whitehead, T. A.; Ekiert, D. C.; Dreyfus, C.; Corn, J. E.; Strauch, E.-M.; Wilson, I. A.; Baker, D. Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin. Science 2011.